Table 1.

Summary of the Clinic-Pathologic Features and Results.

Case	Sex/Age (years)	Tumor Localization	TRK-A (IP)	NGF (RT-PCR)	NGF (WB)	HER-2 (IP)	HER-2 (FISH)	KIT (IP)	SCF (RT-PCR)
Control 1	F/43	Parotid	2+/P	n.d.	n.d.	-	n.d.	2+	n.d.
Control 2	M/42	Parotid	2+/P	+	n.d.	-	n.d.	2+	+
Control 3	F/30	Parotid	2+/P	n.d.	n.d.	-	n.d.	2+	n.d.
Control 4	F/62	Parotid	2+/P	n.d.	n.d.	-	n.d.	2+	n.d.
Control 5	F/83	Parotid	2+/P	+	n.d.	-	n.d.	2+	+
Control 6	M/84	Parotid	2+/P	+	n.d.	-	n.d.	2+	+
Control 7	M/62	Parotid	2+/P	+	+	1+/P	-	2+	+
Control 8	F/54	Submandibular	2+/P	n.d.	+	1+/P	-	2+	n.d.
SDC 1	F/71	Submandibular	3+/P	+	+	-	-	2+	+
SDC 2	F/65	Parotid	3+/P	+	+	3+/PP	+ (HSR)	1+	+
SDC 3	M/63	Parotid	1+/P	+	+	3+/PP	+ (HSR)	-	+
SDC 4	M/79	Parotid	3+/PP	+	+	3+/P	+ (HSR)	-	+
SDC 5	M/58	Parotid	3+/PP	+	+	-	+ (DM)	-	+
SDC 6	M/69	Parotid	2+/PP	+	+	-	-	-	+
SDC 7	F/70	Submandibular	1+/P	+	+	-	-	1+	+
SDC 8	F/48	Parotid	3+/P	+	+	-	+ (DM)	3+/P	+
SDC 9	M/62	Parotid	3+/PP	+	+	1+/P	+(HSR)	1+	+
ACC 1 c	M/55	Submandibular	2+/P	+	+	2+/P	-	2+	+
ACC 2 c	M/17	Parotid	2+/P	+	+	2+/P	-	2+	+
ACC 3 c, t	F/41	Submandibular	1+/PP	n.v.	+	-	-	2+	n.v.
ACC 4 c	F/46	Parotid	2+/P	+	+	-	-	3+	+
ACC 5 c, t, s	F/51	Minor	2+/P	+	+	-	-	3+	+
ACC 6 t	F/52	Minor	2+/P	+	+	2+/P	-	3+/P	+
ACC 7 c, s	F/34	Sublingual	2+/P	+	+	2+/P	-	2+	+
ACC 8 c	F/54	Submandibular	3+/PP	+	+	1+/P	-	3+	+
ACC 9 c, t	F/55	Minor	2+/P	+	+	1+/P	-	3+/P	+
ACC 10 c, s	F/62	Parotid	2+/P	+	+	-	-	3+/P	+
ACC 11 c	F/55	Minor*	3+/PP	+	+	1+/P	-	3+/P	+
ACC 12 c	M/39	Parotid*	3+/P	+	+	1+/PP	-	3+/P	+

The expression and phosphorylation level detected in normal salivary glands was considered as baseline for each receptor (2+/P for TRK-A; 1+/P for HER-2/neu; 2+ for KIT).

c indicates cribriform variety; DM, double minute; F, female; HSR, homogeneously staining region; M, male; n.d., not done; n.v., not evaluable; P, phosphorylation of the receptor; PP, high level of receptor phosphorylation; s, solid variety; t, tubular variety.

^*Recurrence.