Table 1.
Relative activities for ionic currents, as obtained from the literature
| Current | EE | Ref. | LE | Ref. | N | Ref. |
|---|---|---|---|---|---|---|
| INa | 0.08 | Davies et al. (1996) | 1.00 | Davies et al. (1996) | 1.00 | Davies et al. (1996) |
| ICaL | 0.46 | Liu et al. (2002) | 0.78 | Kato et al. (1996, Liu et al. 2002) | 0.78 | Kato et al. (1996) |
| ICaT | 4.50 | Ferron et al. (2002) | 4.50 | Ferron et al. (2002) | 2.90 | Ferron et al. (2002) |
| IK1 | 0.11 | Masuda and Sperelakis (1993) | 1.00 | Kato et al. (1996) | 1.00 | Kato et al. (1996) |
| IKATP | 0.32 | Xie et al. (1997) | 0.88 | Xie et al. (1997) | 1.60 | Xie et al. (1997) |
Relative activities of INa, ICaL, ICaT, IK1, and IKATP for the early embryo (EE), late embryo (LE), and neonatal (N) stage were estimated from the current-voltage (I–V) curves of the cells in vitro. I–V curve of INa was obtained from 11- to 13-dpc (early embryonic), and 17- to 20-dpc (late embryonic) mice; expression of INa reached the adult level in the late embryonic stage (Davies et al. 1996). For ICaL, the early embryonic I–V curve was obtained from 9.5-dpc mice (Liu et al. 2002); the late embryonic I–V curve was obtained from both 18-dpc mice (Liu et al. 2002) and fetal guinea pigs 1–7 days before birth (Kato et al. 1996); the neonatal I–V curve was obtained from neonatal guinea pigs t 1–5 days after birth (Kato et al. 1996). Relative activities of ICaT were obtained on the basis of data for the 14-dpc rat, 18-dpc rat, and 1-day-old rat (Ferron et al. 2002), which corresponded to EE, LE, and N, respectively. For IK1, I–V curves of the 12-dpc rat (Masuda and Sperelakis 1993), the fetal guinea pig 1–7 days before birth (Kato et al. 1996), and the neonatal guinea pig 1–5 days after birth (Kato et al. 1996) were obtained. Relative activities of IKATP were obtained on the basis of data for the 12-dpc rat, 18-dpc rat, and 1-day-old rat (Xie et al. 1997)