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p53 regulates miR-24a expression. HCT cells were treated with genotoxic agents, and cell lysates were assayed for p53, SIRT1, and miR-34a. Acetylation of p53 is increased after treatment with (A) adriamycin and (B) 5-FU. (C) Genotoxic agents increase miR-34a only in HCT cells expressing p53. (D) Genotoxic agents lead to a decrease in SIRT1 levels but only in cells expressing p53.
