Fig. 1.

NRF2 mutations in human cancer. (A) Functional domains of Nrf2 protein showing distribution and types of NRF2 mutations. SQ, lung squamous cell carcinoma; AD, adenocarcinoma; LCNEC, large cell neuroendocrine carcinoma; HN, head and neck cancer; cell, lung cancer cell lines. (B) Representative DNA chromatograph of NRF2 mutations in human cancer cell lines with corresponding normal sequences in the bottom panel. (C) Copy number alteration map [shown by log₂ ratio (tumor/normal)] of chromosome 2 in the tumors with mutated NRF2 and having lost the wild-type allele, detected by array-based comparative genomic hybridization. The arrow indicates the chromosomal location of NRF2. (D) Kaplan–Meier plot showing disease-free survival (DFS) of squamous cell lung carcinoma patients segregated according to the presence or absence of NRF2 mutations.