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. 2008 Aug 29;105(36):13614–13619. doi: 10.1073/pnas.0805493105

Fig. 3.

Fig. 3.

Clozapine (CLZ) in combination with valproate (VPA) induces reelin and GAD67 promoter demethylation in mouse striatum. Mice were pretreated for 7 days with MET (5.2 mmol/kg s.c. twice a day for 7 days). After termination of MET treatment, vehicle (open bars), VPA (0.5 mmol/kg; filled bars), CLZ (15 μmol/kg, shaded bars), or a combination of CLZ and VPA (striped bars) were administered s.c. twice a day for 3 days. Reelin or GAD67 promoter methylation was measured 2 h after the last injection. The data represent the mean ± SE of 3 animals per group. *, P < 0.05 when VPA treated mice were compared with VEH treated mice; **, P < 0.01 when CLZ + VPA treataed mice were compared with VEH + VPA treated mice. One-way ANOVA followed by Bonferroni comparison. ¥, cytosine methylation of reelin and GAD67 promoters was determined as described in Fig. 1.