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. Author manuscript; available in PMC: 2008 Sep 10.
Published in final edited form as: Biochemistry. 2006 Dec 5;45(48):14325–14336. doi: 10.1021/bi0612059

Figure 2.

Figure 2

Sequence alignment of the COG2388 family. Multiple sequence alignment of At1g77540, a putative N-acetyltransferase from Staphylococcus aureus (PDB # 1r57), the histone acetyltransferase Hat1 from Saccharomyces cerevisiae, and 20 seed members of the COG2388 family from the Conserved Domain Database (30). The GenBank accession codes for these seed members are listed in the left column. Secondary structural elements of At1g77540 are represented by cylinders (helices) and arrows (β-strands). The ruler indicates every 5th (*) and 10th (|) residue of At1g77540 is provided for orientation. The number of proteins residues of selected proteins not included in the alignment is shown in brackets. Boxed and shaded areas correspond to motif A (yellow), motif B (pink), and motif D (green) defined for the GNAT family proteins (35) from the structural alignment of At1g77540 and Hat1 (PDB # 1bob). Fully and highly conserved residues are highlighted by bold red letters.