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. Author manuscript; available in PMC: 2008 Sep 10.
Published in final edited form as: J Am Chem Soc. 2007 Jul 11;129(30):9429–9438. doi: 10.1021/ja071879m

Figure 6.

Figure 6

Representative negative ion ToF-SIMS images showing the distribution of DNA and substrate fragments within single (a) unhybridized and (b) hybridized microarray spot. The DNA fragments are localized to the non-contact printed regions but distributed inhomogeneously within the micro-spot. The Si image from the unhybridized probe spot (a) showed a “halo” feature around the spot. Brighter pixel intensity corresponds to higher DNA or substrate signals (counts per pixel). Images are 200 µm ×200 µm.