Table 1.
List of transcripts regulated by rapamycin (Ingenuity classification)
| Inflammation | ||||||
| Upregulated | Downregulated | |||||
| apobec3f | lst1 | adra1a | epha4 | il1rn | ptpn22 | tlr7 |
| blnk | mdm2 | adra2c | f9 | irf2 | ptprc | zeb1 |
| cald1 | oas1 | alpp | fas | itgb3 | ptprz1 | |
| cmklr1 | parvg | bcl11a | faslg | klf2 | rbl2 | |
| ctla4 | pdgfc | bcl2l1 | fcgr2a | lama3 | rbm15 | |
| cxcr4 | rag2 | cast | folr1 | lilra2 | rbpj | |
| cyp3a4 | rela | cd28 | fyb | mll | rel | |
| fyn | sat1 | cd36 | gal | mpo | satb1 | |
| hla-g | tcf12 | clec1b | gap43 | pcgf2 | siglec8 | |
| ifih1 | tfap4 | cul4a | gnrh1 | pla2g6 | smpd1 | |
| ifna2 | thbs1 | cxcl11 | gnrhr | plcg1 | spn | |
| il16 | tlr7 | cyp3a4 | hal-dqb1 | prdm16 | syk | |
| il28b | unc119 | ddl1 | hck | pscdbp | thra | |
| itga4 | vtcn1 | dok2 | ifne1 | ptgs2 | thrb | |
| Cell growth and proliferation | ||||||
| Upregulated | Downregulated | |||||
| adam12 | mdm2 | adra1a | dok2 | gnrh1 | olig2 | rffl |
| blnk | pappa | bcl2l1 | f12 | hck | p53aip1 | sec14l2 |
| cdc2l5 | rag2 | ccl27 | fas | hmga2 | pcgf2 | syk |
| ctla4 | rela | cd28 | faslg | irf2 | pdgfa | tfr2 |
| cxcr4 | s100b | cdca7 | fbxo2 | itgb3 | piwil1 | tgif1 |
| erbb3 | ss18 | clca2 | fcer2 | klf2 | pla2g6 | thra |
| fyn | tcf12 | cltc | fgf18 | lzts1 | ptgs2 | thrb |
| hla-g | thbs1 | csh2 | folr1 | mdm4 | ptk2 | tnfsf15 |
| igf1r | unc119 | cyp2c9 | foxo1 | mll | ptpn22 | zfn10 |
| il28b | vtcn1 | dcc | gal | nab2 | ptpra | |
| itga4 | ddx17 | gap43 | nos1 | ptprc | ||
| lst1 | dll1 | glmn | nov | rbl2 | ||
| Cell death | ||||||
| Upregulated | Downregulated | |||||
| blnk | itga2 | abcd2 | dll1 | hmga2 | p53aip1 | rbm17 |
| cdk6 | mdm2 | acvr1b | eraf | ifne1 | pigt | rel |
| ctla4 | rag2 | adora2a | faf1 | il1rn | piwil1 | satb1 |
| cul3 | rela | atrx | fas | irf2 | pla2g6 | serpinb4 |
| cxcr4 | rnase1 | atxn3 | faslg | itgb3 | pou4f1 | siglec8 |
| cyp2e1 | sgpp1 | bcl2l1 | fcer2 | klf2 | ppp1r9b | smpd1 |
| cyp3a4 | tfap4 | bircabp | foxo1 | klra1 | ppp2r1b | spn |
| erbb3 | thbs1 | cast | gal | lrp5 | prdm2 | stk4 |
| erg | traf4 | ccl27 | gimap5 | mdm4 | ptgs2 | syk |
| fyn | zmym2 | cd28 | gng2 | mll | ptk2 | thra |
| hla-g | cdk6 | gria2 | mpo | ptpn22 | tnfsf15 | |
| ifih1 | cyp2e1 | grik2 | nol3 | ptprc | traf5 | |
| ifna2 | cyp3a4 | grm1 | nos1 | ptprz1 | trps1 | |
| igf1r | dcc | hint1 | nrtn | rbl2 | znf10 | |
| Phagocytosis | ||||||
| Upregulated | Downregulated | |||||
| cd36 | klf2 | |||||
| fas | mpo | |||||
| fcgr2a | pla2g6 | |||||
| hck | syk | |||||
| itgb3 | ||||||
The 1160 mRNAs identified in the microarray screen (as listed in Additional File 2) were plotted onto biological networks using the Ingenuity Pathway Analysis Software package. Those whose protein products are involved in inflammation, phagocytosis, cell growth/proliferation and cell death are listed.