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. 2008 Aug 14;5:76. doi: 10.1186/1742-4690-5-76

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Copyright © 2008 Boxus et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Global model of Tax1 mediated transactivation. Tax1 relieves transcriptional repression of the LTR through direct interaction with HDAC (i.e. HDAC1) and/or HMT (panel A). Tax1 recruits CREB/ATF transcription factors (CA in panel B), histone modifying enzymes and chromatin remodelers (SWI/SNF, P/CAF and CBP/p300). Tax1 then allows binding of basal transcription factors on the TATA box (panel C). Once the initiation complex is formed, Tax1 recruits the P-TEFb factor, leading to CTD phosphorylation and processive elongation (panel D). Finally, interaction of Tax1 with SWI/SNF prevents stalling of transcription elongation. Adapted from [120,132,138,316].