Fig. 5.

Mortality rates and cardiac ceramide levels of LpL^GPI mice. LpL^GPI mice were fed control or myriocin-mixed chow (n = 14 each group) at the age of 12 weeks. Mortality of the mice was documented over the subsequent 40 weeks (A). Cardiac ceramide levels in 6 month-old mice were measured by liquid chromatography/tandem mass spectrometry (B) (n = 5 each group). *P < 0.05 versus WT; ^§P < 0.05 versus LpL^GPI. The mortality of WT mice has been reported previously (19); >90% of these mice survive over 1 year.