TABLE 2.
Heritability estimates and overview of the included covariates
| Covariates
d
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trait | Data Set | No. a | h2 (SEM) b | Variance (%) c | A | A2 | S | A*S | A2*S | C | D | P | E | M | B |
| TC | American Samoa | 553 | 0.37 (0.11) | 19 | + | + | + | − | − | + | − | + | − | − | NE/− |
| Samoa | 646 | 0.59 (0.08) | 23 | + | + | + | − | + | − | − | − | − | − | NE/− | |
| Combined | 1,097 | 0.55 (0.07) | 20 | + | + | + | − | + | + | − | + | − | − | NE/− | |
| HDL | American Samoa | 528 | 0.44 (0.11) | 6 | − | + | + | − | − | − | + | − | − | − | NE |
| 516 | 0.47 (0.11) | 9 | − | − | + | − | − | + | + | − | − | − | + | ||
| Samoa | 518 | 0.41 (0.10) | 5 | + | + | + | − | − | + | + | − | − | − | NE | |
| 517 | 0.40 (N.A.) | 15 | − | − | + | − | − | + | + | − | − | − | + | ||
| Combined | 989 | 0.51 (0.07) | 7 | + | + | + | − | − | + | + | − | + | + | NE | |
| 988 | 0.52 (0.07) | 16 | − | − | + | − | − | + | + | − | + | + | + | ||
| LDL | American Samoa | 560 | 0.34 (0.10) | 17 | + | + | − | − | − | − | − | + | − | − | NE/− |
| Samoa | 518 | 0.71 (0.08) | 18 | + | + | − | + | + | − | + | − | − | − | NE | |
| 517 | 0.69 (0.08) | 20 | + | + | + | + | + | − | + | − | − | − | + | ||
| Combined | 1,021 | 0.57 (0.07) | 17 | + | + | + | − | + | − | + | + | − | − | NE/− | |
| TG | American Samoa | 508 | 0.23 (0.11) | 13 | + | + | + | − | − | − | + | − | + | − | NE |
| 528 | 0.18 (0.10) | 16 | + | + | + | − | − | − | + | − | − | − | + | ||
| Samoa | 634 | 0.48 (0.09) | 20 | + | + | + | + | + | − | − | − | − | + | NE | |
| 515 | 0.46 (0.11) | 27 | + | + | + | + | + | − | + | − | − | + | + | ||
| Combined | 1,006 | 0.41 (0.08) | 15 | + | + | + | − | + | − | + | − | + | + | NE | |
| 1,030 | 0.35 (0.07) | 23 | + | + | + | − | + | − | + | − | − | + | + | ||
A, age; A2, age2; S, sex; A*S, age × sex; A2*S, age2 × sex; B, body mass index; C, cigarette smoker; D, drinking alcohol; P, physical activity; E, education; M, material lifestyle index; N.A., SEM could not be computed by SOLAR; NE, covariate not examined; TC, total cholesterol; TG, triglyceride.
a
Number of included individuals.
b
h2, heritability estimates with SEM for all traits are significantly different from zero (P < 10−2).
c
Variance explained by the included covariates.
d
Minus signs (−) indicate nonsignificant covariates and plus signs (+) indicate significant covariates (P ≤ 0.1) included in the polygenic model.