TABLE 4.
Bivariate multipoint LODeq scores ⩾ 1.9 and test for pleiotropy and coincident linkage
| Cytogenetic Position | Closest Marker(s) | Trait | Data Set | LODeq Score (1 Degree of Freedom) | Covariates a | Complete Pleiotropy b | Coincident Linkage b |
|---|---|---|---|---|---|---|---|
| 6p21-p12 | D6S1610-D6S257 | TC-LDL | Samoa | 2.13 c | A, A2, STC, A•SLDL, A2•S, DLDL | 0.500 | 9.8 × 10−4 |
| 6p21-p12 | D6S1610-D6S257 | TC-LDL | Samoa | 2.25 c | A, A2, S, A•SLDL, A2•S, DLDL, BLDL | 0.500 | 8.1 × 10−16 |
| 7q34-q35 | D7S661 | TC-LDL | American Samoa | 2.62 | A, A2, STC, CTC,P | 0.020 | 0.002 |
| 12p12 | D12S1617 | TC-HDL | Combined | 2.17 c | ATC, A2 TC, S, A2•STC, C, PTC, DHDL, EHDL, MHDL, BHDL | ||
| 12q21 | D12S351 | TC-LDL | American Samoa | 3.38 | A, A2, STC, CTC, P | 0.235 | 5.0 × 10−5 |
| 12q21 | D12S346 | TC-LDL | Samoa | 2.05 c | A, A2, S, A•SLDL, A2•S, DLDL, BLDL | 0.500 | 7.3 × 10−4 |
| 12q23 | D12S78 | TC-TG | Combined | 2.58 c | A, A2, S, A2•S, CTC, PTC, DTG, MTG, BTG | 0.028 | 0.625 |
| 12q24 | D12S1723 | TC-TG | Combined | 2.26 c | A, A2, S, A2•S, CTC, PTC, DTG, MTG, BTG | ||
| 12q24 | D12S1723 | TC-HDL | Combined | 3.22 c | A, A2, S, A2•STC, C, PTC, DHDL, EHDL, MHDL | 0.008 | 0.017 |
| 12q24 | D12S1723 | TC-HDL | Combined | 3.00 c | ATC, A2 TC, S, A2•STC, C, PTC, DHDL, EHDL, MHDL, BHDL | N.A. | N.A. |
| 19p13-q12 | D19S226-D19S414 | TC-LDL | American Samoa | 2.14 | A, A2, STC, CTC, P | 0.395 | 0.001 |
a
Covariates included in the polygenic model. Subscripts indicate trait-specific covariates.
b
P value for test of complete pleiotropy (ρq constrained to 1 or −1) and no coincident linkage (ρq constrained to 0) for the maximum LODeq per chromosome. N.A. indicates that convergence failure occurred in SOLAR.
c
The corrected LOD score (LODmtc) can be calculated by subtracting 0.3 from the uncorrected LOD score shown. LODeq ⩾ 3 is indicated in boldface.