TABLE 3.

Acetyl-CoA enrichment and de novo palmitate synthesis

	Acetyl-CoA Enrichment		Palmitate from de Novo Synthesisa
Group	Average ± SD	P	Average ± SD	P
[U-13C]stearate experiment
A (control)	0.128 ± 0.0019		0.536 ± 0.0027
B	0.128 ± 0.0015	0.484	0.538 ± 0.0047	0.298
C	0.135 ± 0.0011	0.003	0.513 ± 0.0100	0.009
D	0.130 ± 0.0008	0.052	0.520 ± 0.0184	0.104
[U-13C]palmitate experiment
A (control)	0.177 ± 0.005		0.465 ± 0.021
B	0.185 ± 0.008	0.102	0.496 ± 0.003	0.033
C	0.198 ± 0.003	0.002	0.479 ± 0.026	0.262
D	0.174 ± 0.007	0.250	0.460 ± 0.037	0.412

^aOf the fraction of palmitate that is not derived from chain shortening of fully labeled stearate (see Table 2), about 51–54% is from de novo synthesis of palmitate (m₂, m₄, etc.) and the remainder is from preexisting unlabeled palmitate. Of the fraction of palmitate that is not fully labeled, about 46–49% is from de novo synthesis of palmitate (m₂, m₄, etc.) and the remainder is from preexisting unlabeled palmitate.