. Author manuscript; available in PMC: 2008 Sep 11.

Published in final edited form as: J Med Chem. 2007 Mar 21;50(8):1828–1839. doi: 10.1021/jm061304k

Table 4.

Activity of d-3′-F-C-d4G against lamivudine-resistant virus (HIV-1_M184V) in human PBM Cells using carbovir as control

Compounds	xxBRU		M184V		FI^a
	EC₅₀ (μM)	EC₉₀ (μM)	EC₅₀ (μM)	EC₉₀ (μM)
	d-3′-F-C-d4G 35	0.098	0.58	3.8		14.9	38.8
Carbovir^b	0.087	0.27	0.20	1.1	2.3

FI is the fold increase (EC₅₀ HIV-1_M184V / EC₅₀ HIV-1_xxBRU).

We also performed the experiment using AZT and 3TC as control, in which AZT is not but 3TC is highly cross-resistant to M184V mutant, and compound 35 is cross-resistant to M184V mutant (data not shown).