. Author manuscript; available in PMC: 2008 Sep 11.

Published in final edited form as: J Med Chem. 2007 Mar 21;50(8):1828–1839. doi: 10.1021/jm061304k

Table 5.

In vitro anti-HIV activity of selected 3′-F-C-d4Ns and carbovir against HIV wild type virus and correlation with calculated energy of complex (Inhibitor-TP) / HIV-RT

Compound	EC₅₀ (μM)^a	Erel (Kcal/mol)^c
d-3′-F-C-d4G 35	0.41	−24.4
l-3′-F-C-d4G 28	20.7	+18.8
Carbovir	0.087^b	-10.8

EC₅₀ in PBM cells against HIV-1_LAI unless otherwise indicated.

EC₅₀ in PBM cells against HIV-1_xxBRU.

E_rel = (Binding energy of inhibitor-TP) – (Binding energy of natural 2′-dNTP).