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. Author manuscript; available in PMC: 2008 Sep 11.
Published in final edited form as: J Org Chem. 2006 Jan 20;71(2):629–635. doi: 10.1021/jo052030w

Scheme 5. Synthesis of Ether-linked Probes 2 and 4.

Scheme 5

(a) (i) CH3SO2Cl, Et3N, 0 °C-rt; (ii) LiBr, THF, reflux; (b) (i) (n-Bu)2SnO, CHCl3/MeOH (10:1), reflux; (ii) 28, CsF, 18-crown-6, DMF, rt, 1 d; (c) MOMCl, i-Pr2NEt, CH2Cl2; (d) CAN, CH3CN/H2O (6:1); (e) (i) DGK, [32P]ATP; (ii) TMSBr, CH2Cl2, 0 °C.