TABLE 1.
Selected pharmacokinetic parameters of isoniazid and rifabutin delivered via the intravenous and inhalation routes in the serum of micea
| Drug and route | Cmax (μg·ml−1) | AUCOBSb (μg·ml−1·h−1) | t1/2 (h) | Vz (ml) | CL (ml·h−1) |
|---|---|---|---|---|---|
| Isoniazid | |||||
| Intravenous | 3.24 ± 0.57 | 16.64 ± 1.80 | 3.91 ± 1.06 | 41.34 ± 14.92 | 4.43 ± 1.85 |
| Inhalation | 2.37 ± 0.23 | 55.34 ± 13.72 | 18.62 ± 5.89 | 1,667.78 ± 48.09 | 63.90 ± 13.32 |
| Rifabutin | |||||
| Intravenous | 3.47 ± 0.33 | 90.82 ± 7.46 | 20.18 ± 4.02 | 29.52 ± 4.29 | 1.02 ± 0.11 |
| Inhalation | 1.59 ± 0.01 | 109.35 ± 14.78 | 119.49 ± 29.62 | 2,308.84 ± 137.78 | 11.68 ± 7.00 |
a
Values are means ± standard deviations.
b
AUCOBS, observed area under the concentration-time curve.