FIG. 4.

Survival of immunocompromised WT mice. In the first survival assay (A), mice were infected intranasally with DsRed A. fumigatus conidia and treated with vehicle control (♦) or with one dose of C16-KAAK at 4.5 mg/kg day after the infection (▴) or with four doses of C16-KAAK at 4.5 mg/kg every day from the day of the infection (▪) or with one dose of AMB at 1 mg/kg day after the infection (•), or with four doses of AMB at 1 mg/kg every day from the day of the infection (−). Survival was followed over a period of 14 days. In the second survival assay (B), treatments were given on days 1, 4, 7, and 11, and survival was followed over a period of 21 days: vehicle control (♦), C16-KAAK at 4.5 mg/kg (▴), AMB at 1 mg/kg (•). In both assays, infected immunocompetent mice served as a control (▪). Two independent reproducible experiments were done.