TABLE 1.

Structures of the quinoxaline derivatives and previously reported in vitro activities against M. tuberculosis^a

^aData are from reference 15.

^bThe SI is the selectivity index calculated as the concentration inhibiting the growth of Vero cells in culture by 50% following 72 h of exposure (assessed using the CellTiter 96 nonradioactive cell proliferation assay reagent from Promega) divided by the MIC. L 2, assay level 2 according to the TAACF assay program.

^cEC₉₀/MIC is a measure of the activity against intracellular M. tuberculosis taken up by mouse bone marrow macrophages, calculated as the 90% effective concentration (EC₉₀), or the concentration required to inhibit the growth of intracellular M. tuberculosis by 90%, divided by the MIC. L 3, assay level 3 according to the TAACF assay program.