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Amino acid changes resulting from mutations in gyrA coding sequence and the associated MICs of NXL101 and ciprofloxacin of the host S. aureus strain
| WT or mutant strain | MIC (mg liter−1)
|
|
|---|---|---|
| NXL101 | Ciprofloxacin | |
| Robine | ||
| WT | 0.12 | 0.5 |
| His81Asn mutant | 16 | 0.5 |
| Goodtime | ||
| WT | 0.12 | 4 |
| Arg92Cys mutant | 4 | 4 |
| Bontempsa | ||
| WT | 1 | 4 |
| Met121Lys mutant | 64-128 | 4 |
| Asp83Gly mutant | 16-32 | 4 |
The two mutants and corresponding MICs for the Bontemps strain represent two separate experiments.
