TABLE 5.

Activities of HCV-796 on HCV NS5B enzyme variants

Enzyme	IC50a (nM) ± SD	Susceptibility relative to wild-type enzymeb
1b BB7 (C316)	40 ± 20 (n = 35)
1b BB7-C316N	81 ± 42 (n = 4)	−2
1b BB7-C316Y	320 ± 10 (n = 3)	−8
1b BB7-C316F	1,508 ± 419 (n = 3)	−124
1b BB7-M414V	28 ± 2 (n = 3)	+1.4
1b BB7-M414I	24 ± 6 (n = 3)	+1.7
1b BB7-I363V	60 ± 10 (n = 3)	−1.5
1b BK (N316)	140 ± 50 (n = 33)
1b BK-N316C	31 ± 4 (n = 3)	+4.5

^aIC₅₀, 50% inhibitory concentration.

^bn-fold more (+) or less (−).