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Geometric mean plasma concentration-time curves of artemisone and its three major metabolites (M1, M2, and M3) following administration of multiple doses of artemisone to healthy subjects. (A) A 3-day course of 40 mg (two 20-mg immediate-release tablets) artemisone daily administered to eight healthy subjects. (B) A 3-day course of 80 mg (four 20-mg immediate-release tablets) artemisone daily administered to seven healthy subjects.
