FIG. 4.

Intestinal epithelium infection summary scores for C. parvum-infected neonatal mice in different treatment groups. The cumulative score for the extent of intestinal infection was calculated as the sum of the numbers of trophozoites per 1,000 epithelial cells from all of the tissue sections for each mouse. Treatment group data are presented in box plots displaying the median values (21,159, 10, 13,750, and 63 for the paromomycin no-drug control, paromomycin, the pyrvinium no-drug control, and pyrvinium, respectively). A Kruskal-Wallis nonparametric test of equality and pairwise comparisons using a nonparametric two-sample Mann-Whitney test showed that the levels of trophozoites in both the pyrvinium and the paromomycin treatment group were significantly (P < 0.05) lower than those in their respective controls but not significantly different from each other (P = 0.2682).