Parasitemia levels (A and E), parasitemia peak at 8 dpi (B and F), mortality rates (C), and mean weights at 21 dpi (D) of mice infected with the Y strain of T. cruzi and treated with DB1362 or Bz at 5 and 8 dpi (A to D) and 3 to 12 dpi (E and F). The single asterisk indicates significant differences between T. cruzi-infected mice and uninfected mice (P ≤ 0.05). Double asterisks indicate significant differences between T. cruzi-infected, treated mice and infected, untreated animals (P ≤ 0.05).