FIG. 5.

Parasitism and inflammatory infiltrates in the heart (A) and ECG findings (B and C) for mice infected with T. cruzi and treated with DB1362 or Bz or left untreated. (A) Parasitism and inflammatory infiltration were decreased by diamidine and Bz treatment. (B) Mean cardiac frequencies were determined by ECG analysis in uninfected, infected but untreated, Bz-treated, and DB1362-treated mice. The single asterisk indicates significant differences between T. cruzi-infected mice and uninfected mice (P ≤ 0.05). Double asterisks indicate significant differences between T. cruzi-infected, treated mice and infected, untreated animals (P ≤ 0.05). (C) Representative electrocardiographic tracing of uninfected, infected but untreated, Bz-treated, and DB1362-treated mice. Note the normal patterns in uninfected mice and the variations in the heart rate (traced lines) for infected but untreated animals, which were partially recovered in both drug-treated groups.