TABLE 4.

SQV PK parameters after SQV addition (step 2)

Parameter (unit of measure)	Result [median (range)] for:
	Group 1 (n = 13)	Group 2 (n = 3)	Overall (n = 16)
AUC (μg ·h/ml)	33.9 (4.4-76.5)	32.1 (4.4-33.3)	33.7 (4.4-76.5)
Cmax (μg/ml)	3.5 (0.8-8.3)	3.6 (0.6-4.0)	3.6 (0.6-8.3)
C0h (μg/ml)	1.83 (0.11-4.66)	2.05 (0.41-2.42)	1.88 (0.11-4.66)
C12h (μg/ml)	2.18 (0.05-4.86)	1.45 (0.05-2.58)	1.82 (0.05-4.86)
C0h and C12h avg (μg/ml)	2.2 (0.4-4.1)	1.9 (0.2-2.3)	2.1 (0.2-4.1)
CL (liter/h/m2)	22.8 (8.9-184.5)	23.9 (22.2-147.6)	23.1 (8.9-184.5)
Tmax	3.0 (0-6.0)	6.0 (2.0-6.0)	3.0 (0-6.0)