TABLE 1.
Gene mutations in 23S rRNA and clarithromycin susceptibility in transformants with low-level clarithromycin resistance
| Strain | Donor DNA (region of the 23S rRNA gene)a | MIC (mg/liter) | Nucleic acid in E. coli (H. pyloria) 23S rRNA at position:
|
||||
|---|---|---|---|---|---|---|---|
| 2058 (2142) | 2059 (2143) | 2098 (2182) | 2106 (2190) | 2611 (2694) | |||
| ATCC 700392 (recipient) | ≤0.008 | A | A | T | T | C | |
| S1900 (donor) | 1 | A | A | C | C | A | |
| TF1 | 626-2774 | 0.5 | A | A | C | C | A |
| TF2 | 1931-2774 | 0.25 | A | A | C | C | A |
| TF3 | 2276-2774 | 1 | A | A | T | T | A |
| TF4 | 2569-2774 | 1 | A | A | T | T | A |
a
Positions correspond to the 23S rRNA gene of UA802 (GenBank accession no. U27270).