TABLE 2.
Effects of CPPs on the establishment of P. falciparum (3D7 clone) sporogonic development in the mosquito vector A. gambiae following a gametocyte membrane feeding
| Expt no. | CPP treatment | No. of oocyst-positive mosquitoes/total no. dissected (% prevalence of oocyst infection) | Median no. of oocysts/infected mosquito (range) |
|---|---|---|---|
| 1 | TP10 | 21/42 (50)a | 2 (1-6)b |
| pVEC | 25/40 (63)a | 2 (1-23) | |
| Control (no CPP) | 37/40 (93) | 4 (1-11) | |
| 2 | TP10 | 13/43 (30) | 1 (1-3) |
| pVEC | 19/43 (44) | 2 (1-5) | |
| Control (no CPP) | 23/47 (49) | 1 (1-5) | |
| 3 | TP10 | 17/34 (50)a | 4 (1-43) |
| pVEC | 24/35 (69) | 4 (1-24) | |
| Control (no CPP) | 31/40 (78) | 4 (1-29) |
a
Significantly different (P of <0.0001, P equals 0.0013, and P equals 0.01 for TP10 [experiment 1], pVEC [experiment 1], and TP10 [experiment 2], respectively) from the value of control mosquitoes infected, as calculated using chi-squared or Fisher's exact tests.
b
Significantly different (P of <0.0001 for TP10 [experiment 1]) from the value of oocyst densities, as calculated using the Genmod procedure.