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Arithmetic mean plasma raltegravir concentrations following multiple doses of raltegravir (RAL) at 400 mg twice daily with and without coadministration of multiple doses of TDF alone at 300 mg once daily or TDF at 300 mg once daily plus lamivudine (3TC) at 300 mg once daily. (A) Healthy young men (n = 9 [inset, semilog scale]). (B) Treatment-naïve HIV-positive patients (n = 6 [inset, semilog scale]).
