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. Author manuscript; available in PMC: 2008 Sep 11.

Published in final edited form as: Bioconjug Chem. 2006;17(4):1057–1062. doi: 10.1021/bc060028l

Circular Dichroism of Melittin Analogues. The CD spectra of M0 ( ), M6 (◆), M11 (●) and M14 (■) acquired in 40% trifluoroethanol (v/v) in 10 mM pH 7.4 phosphate buffer at 25 °C are compared. The results establish that M11 was unable to form an α-helix, thereby accounting for its lack of hemolytic activity and gene transfer efficiency.

Inline graphic — Circular Dichroism of Melittin Analogues. The CD spectra of M0 ( ), M6 (◆), M11 (●) and M14 (■) acquired in 40% trifluoroethanol (v/v) in 10 mM pH 7.4 phosphate buffer at 25 °C are compared. The results establish that M11 was unable to form an α-helix, thereby accounting for its lack of hemolytic activity and gene transfer efficiency.