Table 2.
Recombination scheme for the anti-TB fractions used to produce the cocktails for synergy evaluation
From the left: cocktail mix number, contents, expected activity in case of no interaction, concentration for the expected activity, detailed concentrations for each fraction.
| Cocktails | Ingredients | Expected inhibition (%) | Conc (µg/ml) | Concentrations for each component fraction (µg/ml) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B11 | B12 | B13 | |||||||||||
| mix 1 | B12+B13 | 40 | 32 | - | 16.29 | 15.71 | |||||||
| mix 2 | B11−B13 | 40 | 32 | 3.00 | 8.28 | 20.72 | |||||||
| B21 | B22 | B23 | B24 | B25 | B26 | B27 | |||||||
| mix 3 | B23−B26 | 40 | 32 | - | - | 6.28 | 23.30 | 0.78 | 1.64 | - | |||
| mix 4 | B23−B27 | 40 | 64 | 10.39 | 10.39 | 2.90 | 22.31 | 3.15 | 4.47 | 10.39 | |||
| mix 5 | B21−B25 | 80 | 64 | 4.54 | 13.33 | 8.74 | 28.43 | 8.96 | - | - | |||
| B31 | B32 | B33 | B34 | B35 | B36 | B37 | B38 | B39 | B310 | ||||
| mix 6 | B36−B310 | 40 | 32 | - | - | - | - | - | 8.53 | 2.82 | 13.71 | 4.39 | 2.55 |
| mix 7 | B31−B28 | 40 | 64 | 22.68 | 0.50 | 0.50 | 0.50 | 8.66 | 7.35 | 8.71 | 15.10 | - | - |