TABLE 2.

Herpes simplex virus (HSV) type-specific serology for genital herpes

HSV serology should be performed only with glycoprotein G-based tests. HSV type-specific serology is considered beneficial in selected populations who meet specific clinical criteria as outlined below
HSV-2 serology is indicated for diagnosing genital herpes in:
Patients with recurrent or atypical genital lesions in whom a diagnosis has not been confirmed by antigen detection, culture or PCR.
Asymptomatic patients who have a history suggestive of genital herpes.
Patients diagnosed with HIV infection.
HSV-2 serology, with HSV-1 serology as appropriate, is indicated for evaluating infection and or immune status in:
Couples discordant for genital herpes.
Women who develop their first clinical episode of genital herpes during pregnancy.
Asymptomatic pregnant women whose partners have a history of genital herpes or HIV infection.
Women contemplating pregnancy or considering sexual partnership with an individual with a history of genital herpes.
Universal screening of pregnant women for HSV is not recommended.

The above testing should be offered in conjunction with education on HSV and preventive counselling. Although the tests are highly specific, there is potential for false-positive results. Results should be interpreted in the context of clinical presentation and patient history. PCR Polymerase chain reaction