TABLE 2.

Percentages of infants with solicited systemic reactions in the 72 h after immunization with fully liquid DTaP-IPV-Hib vaccine at two, four, six, and 18 months of age, presented with historical data with reconstituted DTaP-IPV//Hib vaccine for comparison

		Any systemic reaction after indicated vaccine (%)*
Systemic reaction	Age (months)	DTaP-IPV-Hib	DTaP-IPV//Hib†
Fever (38.0°C or higher)	2	15.1	25.7
	4	25.8	27.0
	6	23.5	20.2
	18	32.8	32.1
Fussiness	2	56.1	54.3
	4	56.8	62.9
	6	48.2	45.3
	18	37.2	40.5
Crying	2	39.2	40.9
	4	45.3	50.2
	6	30.9	35.1
	18	25.9	28.4
Less active	2	49.6	52.2
	4	34.2	34.3
	6	17.9	22.7
	18	15.3	13.4
Decreased eating	2	37.1	36.7
	4	27.9	28.3
	6	23.6	25.5
	18	21.9	25.1
Vomiting	2	12.2	13.7
	4	9.0	8.5
	6	7.0	9.6
	18	7.6	8.7
Diarrhea	2	20.2	16.4
	4	10.2	12.5
	6	13.0	13.7
	18	12.3	11.0

^*The number of subjects evaluated after doses 1 to 4, respectively, were: diphtheria, tetanus and acellular pertussis, inactivated polio vaccine and Haemophilus influenzae type b (DTaP-IPV-Hib) – 338, 333, 330 and 301, and DTaP-IPV//Hib – 335, 329, 323 and 299;

^†Data on file (sanofi pasteur, Canada)