TABLE 3.

Antibody responses to diphtheria, tetanus toxoid and poliovirus types 1, 2, and 3 after primary series and before and after booster immunization of infants with fully liquid DTaP-IPV-Hib vaccine

Antigen	Result	Antibody responses at indicated age
		7 months (n=324)	18 months (n=301)	19 months (n=301)
Diphtheria	GMC, IU/mL	0.29	0.05	4.13
	95% CI	0.22–0.38	0.04–0.06	3.58–4.76
	% ≥0.01 IU/mL	100	92.0	100
	% ≥0.10 IU/mL	78.7	27.2	100
Tetanus*	GMC, EU/mL	2.86	0.53	10.1
	95% CI	2.62–3.14	0.48–0.59	9.33–11.0
	% ≥0.01 EU/mL	100	99.3	100
	% ≥0.10 EU/mL	99.7	96.7	100
Polio type 1	GMT, titre–1	713	110	8025
	95% CI	526–723	97–137	6649–9160
	% titre–1 ≥8	100	94.1	100
Polio type 2	GMT, titre–1	2520	306	19,451
	95% CI	2026–2800	256–377	15,052–20,486
	% titre–1 ≥8	100	99.0	100
Polio type 3	GMT, titre–1	1458	143	13,613
	95% CI	1079–1485	115–172	10,305–14,962
	% titre–1 ≥8	100	94.2	100

^*Tetanus antitoxin values standardized for change in ELISA assay between seven and 18 months by multiplying seven-month values by 2.62. DTaP-IPV-Hib Diphtheria, tetanus and acellular pertussis, inactivated polio vaccine and Haemophilus influenzae type b;

GMC Geometric mean antibody concentration;

GMT Geometric mean antibody titre