TABLE 6.
Antibody responses to immunization with fully liquid (DTaP-IPV-Hib) or reconstituted (DTaP-IPV//Hib) acellular pertussis combination vaccines in infants at two, four, six and 18 months of age
| Antibody to | Result | Antibody responses to indicated vaccine at indicated age, months
|
|||||
|---|---|---|---|---|---|---|---|
| Fully liquid
|
Reconstituted
|
||||||
| 7 (n=324) | 18 (n=301) | 19 (n=301) | 7 (n=323) | 18 (n=298) | 19 (n=300) | ||
| PRP, μg/mL | GMC | 4.40 | 0.42 | 30.1 | 4.86 | 0.55 | 32.3 |
| Diphtheria | GMT | 0.28 | 0.05 | 4.42 | 0.29 | 0.05 | 4.13 |
| Tetanus* | GMT | 2.31 | 0.40 | 7.52 | 2.86 | 0.53 | 10.1 |
| PT | GMT | 89.0 | 11.4 | 181.7 | 86.7 | 11.9 | 221.7 |
| FHA | GMT | 152.6 | 20.9 | 244.6 | 155.0 | 19.9 | 265.9 |
| PRN | GMT | 55.9 | 9.55 | 210.3 | 55.4 | 9.31 | 207.7 |
| FIM 2 and 3 | GMT | 243.8 | 37.9 | 855 | 277 | 38.4 | 842 |
| Polio 1 | GMT | 723 | 108 | 14874 | 713 | 110 | 8025 |
| Polio 2 | GMT | 2178 | 303 | 21690 | 2520 | 306 | 19451 |
| Polio 3 | GMT | 1942 | 243 | 22930 | 1458 | 143 | 13613 |
*
Tetanus antitoxin values standardized for change in ELISA assay between seven and 18 months by multiplying seven-month values by 2.62. DTaP-IPV-Hib Diphtheria, tetanus and acellular pertussis, inactivated polio vaccine and Haemophilus influenzae type b;
FHA Filamentous hemagglutinin;
FIM Fimbriae;
GMC Geometric mean antibody concentration;
GMT Geometric mean antibody titre;
PRN Pertactin;
PRP Polyribosylribitol phosphate;
PT Pertussis toxoid