Table 2.
Controls Frequencies (%) |
UC patients Frequencies (%) |
P-value | OR (95% CI)* | |
MTHFR 677 | ||||
CC# | 40.9 | 38.1 | ||
CT# | 43.3 | 45.2 | 0.6053a | 1.12 (0.72–1.75) |
TT | 15.8 | 16.7 | 0.6821a | 1.13 (0.62–2.05) |
Total number of patients analysed | 215 | 168 | ||
Allele T | 0.37 | 0.39 | 0.6027 | 1.09 (0.81–1.46) |
MTHFR 1298 | ||||
AA# | 66.2 | 69.4 | ||
AC | 29.1 | 28.1 | 0.7277a | 0.92 (0.58–1.46) |
CC | 4.7 | 2.5 | 0.2631a | 0.51 (0.15–1.66) |
Total number of patients analysed | 213 | 160 | ||
Allele C | 0.19 | 0.17 | 0.3455 | 0.86 (0.59–1.26) |
MTR 2756 | ||||
AA# | 83.5 | 73.7 | ||
AG | 15.1 | 23.1 | 0.0422a | 1.72 (1.02–2.92) |
GG | 1.4 | 3.2 | 0.1899a | 2.64 (0.62–11.25) |
Total number of patients analysed | 218 | 156 | ||
Allele G | 0.09 | 0.15 | 0.0137 | 1.81 (1.15–2.84) |
MTRR 66 | ||||
AA# | 58.0 | 53.7 | ||
AG | 35.6 | 38.4 | 0.4839a | 1.17 (0.76–1.79) |
GG | 6.4 | 7.9 | 0.4746a | 1.34 (0.60–2.99) |
Total number of patients analysed | 219 | 164 | ||
Allele G | 0.24 | 0.27 | 0.2401 | 1.18 (0.85–1.64) |
TCN2 776 | ||||
CC# | 21.8 | 18.5 | ||
CG | 38.9 | 45.2 | 0.3358a | 1.26 (0.79–2.01) |
GG | 39.3 | 36.3 | 0.7835a | 1.09 (0.61–1.95) |
Total number of patients analysed | 216 | 146 | ||
Allele G | 0.58 | 0.59 | 0.9447 | 1.0 (0.74–1.35) |
*(OR: unadjusted odds ratio; 95 CI%: 95% confidence interval)
Abbreviations :methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methylenetetrahydrofolate reductase (MTRR) and transcobalamin (TCN2)
# Dominant genotype. a Comparison with dominant genotype.