Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Channel occlusion. (A) Consecutive snapshots from the AQP0NJ4 simulation. The water pathway is pinched off by intrusion of loop A (yellow) while loop C (light blue) remains stationary. The lumen dries out on occlusion, but rehydrates later in the simulation (Lower Middle and Bottom) after loop A reopens. (B) Extracellular view. His-40, Arg-33, and Trp-34 are shown as spheres. Trp-34 slides between loops A and C, thereby occluding the channel.
