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. Author manuscript; available in PMC: 2008 Sep 18.
Published in final edited form as: Eur J Neurosci. 2007 Jul;26(2):289–301. doi: 10.1111/j.1460-9568.2007.05671.x

Figure 2. Effects of the blockade of NR2B-containing receptors on the potentiation of layer 5 pyramidal neurons inputs for P18–P23 old rats.

Figure 2

(A) The left column shows representative recordings before HFS application and the right column 60 min after application of HFS in layer 2/3 in the presence of 1 μM Ro 25-6981. Upper traces: current responses of a layer 5 pyramidal neuron to electrical stimulation. Imposed membrane potential ranged for −55 to −75 mV. The amplitude of current responses was unchanged after HFS application in the presence of Ro 25-6981. Medium traces: decomposition of the responses in total conductance change (gT). Lower traces: decomposition of gT in excitatory and inhibitory conductance changes (gE, dark grey and gI, light grey).

(B) Relative changes (compared to control) of intgT (black bars), intgE (dark grey bars) and intgI (light grey bars), after HFS in layer 2/3 (n = 12) in the presence of 1 μM Ro 25-6981.

(C) Relative contribution of excitation and inhibition conductance changes to the total conductance change, after HFS in the presence of 1 μM Ro 25-6981 (c:control before HFS protocol).

(D-E-F) Application of HFS protocol in the presence of 10 μM CP101,606 (n = 18). Legends are identical to those in A-B-C. No variations of total, excitatory and inhibitory conductance changes were observed after HFS (D-E) and the E/I ratio was unchanged (F).