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. Author manuscript; available in PMC: 2008 Sep 12.

Published in final edited form as: Alcohol Clin Exp Res. 2007 Dec 7;32(1):67–76. doi: 10.1111/j.1530-0277.2007.00554.x

Table 2.

Effects of mGluR Antagonists on Loss of Righting Reflex Induced by GABAergic and Glutamatergic Sedative-Hypnotics

	MPEP dose (mg / kg)				LY341495 dose (mg / kg)
	0		30		0		30
	Onset	Duration	Onset	Duration	Onset	Duration	Onset	Duration
Pentobarbital (50 mg / kg)	3.6 ± 0.4	63.9 ± 3.5	3.6 ± 0.5	56.3 ± 2.1	8.1 ± 0.7	46.2 ± 11.5	12.3 ± 0.9^*	15.1 ± 7.6^*
Midazolam (60 mg / kg)	10.6 ± 2.5	47.3 ± 3.2	6.2 ± 1.2	47.5 ± 3.6	25.5 ± 7.3	39.6 ± 8.2	0.0 ± 0.0^*	0.0 ± 0.0^*
Ketamine (200 mg / kg)	1.4 ± 0.1	41.0 ± 1.3	1.4 ± 0.1	56.8 ± 1.1^*	2.7 ± 0.6	40.2 ± 1.9	2.1 ± 0.1	32.3 ± 1.3^*

Data expressed as mean ± SEM minutes (n = 8 to 10).

^*

Significantly different from pentobarbital, midazolam, or ketamine alone (p < 0.05, Tukey’s test).