Table 3.
Effects of mGluR Antagonists on Blood-Ethanol Concentration
| Time interval (min)
|
||||||
|---|---|---|---|---|---|---|
| 10 | 30 | 60 | 120 | 180 | AUC | |
| Saline | 387.1 ± 18.6 | 381.6 ± 8.4 | 369.4 ± 6.9 | 314.7 ± 7.9 | 255.6 ± 8.8 | 57197.8 ± 1568.9 |
| MPEP | 391.2 ± 22.4 | 399.5 ± 14.6 | 387.1 ± 11.0 | 330.8 ± 11.3 | 275.5 ± 12.7 | 60347.3 ± 2627.5 |
| Cyclodextrin | 390.7 ± 10.9 | 406.2 ± 5.6 | 385.4 ± 8.4 | 353.0 ± 5.9* | 314.6 ± 6.1* | 62026.1 ± 680.4* |
| LY341495 | 399.9 ± 17.3 | 381.5 ± 11.6 | 379.3 ± 14.3 | 333.7 ± 16.0 | 305.8 ± 10.9 | 59802.8 ± 2008.8 |
AUC, mean area under the curve ± SEM.
Data expressed as mean ± SEM mg / dl (n = 7 to 16).
Significantly different from saline (Tukey; p < 0.05).