Figure 3.

Bar graphs of selected biodistribution data obtained from co-injections (¹²⁵I- and α-emitter ²¹³Bi-or ²¹¹At-labeled) modified rSAv. ¹²⁵I-labeled modified rSAv data are plotted as black bars in each panel. ²¹³Bi or ²¹¹At biodistribution data are plotted as grey bars. Panel A shows tissue distributions of ²¹³Bi-labeled succinylated rSAv-CHX-A″, [²¹³Bi]6a, in comparison with ¹²⁵I-labeled succinylated rSAv-CHX-A″, [¹²⁵I]6b, at 1.5 h (1^st pair of bars) and 3 h (2^nd pair of bars) pi. Panel B shows tissue distributions of ²¹¹At- and ¹²⁵I-labeled succinylated rSAv that had no boron cage conjugated, [²¹¹At]2b and [¹²⁵I]2b, at 4 (1^st pair of bars) and 24 h (2^nd pair of bars) pi. Panel C shows tissue distributions of ²¹¹At- and ¹²⁵I-labeled succinylated rSAv that had nido-carborane cages conjugated, [²¹¹At]6c and [¹²⁵I]6c, at 4 and 24 h pi. Panel D shows tissue distributions of ²¹¹At- and ¹²⁵I-labeled succinylated rSAv that had decaborate(2-) cages conjugated, [²¹¹At]6d and [¹²⁵I]6d, at 4 and 24 h post injection. Tables (S1–S4) of biodistribution data are provided in Supporting Information.