FIGURE 7.

D₁–D₃ behavioral receptor interactions in reserpinized Swiss Webster mice. Effects of the D₃ receptor agonist PD 128907 (PD, 0.3–3 mg/kg, i.p.) on the locomotor activation induced by the D₁ receptor agonist SKF 38393 (SKF, 15 mg/kg, i.p.) and/or the D_2–3 receptor agonist quinpirole (Quinp, 0.5 mg/kg, i.p.) in reserpinized mice. Results represent means ± S.E. of the average of the values obtained during 10-min periods of the first hour of recording. ^* and ^**, significantly different compared with SKF (ANOVA: p < 0.05 and p < 0.01, respectively); ^##, significantly different compared with SKF+Quinp without PD co-administration (ANOVA: p < 0.01).