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H1 reduces the number of replication foci in sperm nuclei. Metaphase-arrested egg extracts were treated with the protein kinase inhibitor 6-DMAP and released into interphase by Ca2+ addition. Sperm chromatin was then added to released extract supplemented with biotin-dUTP and H1 (H1) or without H1 (Control) and incubated for 3 h. A confocal series of optical sections taken at 0.5-μm intervals through two control nuclei and two H1 nuclei stained with Texas-Red streptavidin are shown.
