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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Int J Biochem Cell Biol. 2008 Mar 6;40(10):2206–2217. doi: 10.1016/j.biocel.2008.02.025

Fig. 2.

Fig. 2

Schematic drawing of the interactions between the cofactor CH2THF and wild-type TS in the crystal structure of the ternary complex with FdUMP. Water molecules are represented by W, hydrogen-bonds are represented with dashed lines and van der Waals contacts with vertical broken lines. Note the water-mediated hydrogen-bond between the glutamate tail of cofactor and the lysine residue at position 48 of wild-type TS.