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Immune response to VACV-WR; scarification vs i.p. immunization. Average responses of immunodominant epitopes, measured by IFN-γ expression in ELSIPOT assays, following VACV-WR immunization either by scarification (□) or i.p. infection (▪) are shown (A). Column bars of the percent relative responses to each identified VACV-WR-derived epitopes in either route of administration are also shown (B).
