Table II.
Structural characteristics of recognized Ags
| Copenhagen Name | VACV-WR Name | Protein length (aa) | Time of Expression | Function | Life Cycle |
|---|---|---|---|---|---|
| NC | 16 | 77 | Unknown | Gene fragment, ankyrin-like 77-kDa cowpox host range | Unknown |
| NC | 148 | 725 | Late | gene fragment, cowpox A-type inclusion protein | Structural protein |
| A ORF K | A ORF K | 70 | Unknown | Unknown | Unknown |
| A3L | 122 | 644 | Late | p4b precursor of core protein 4b | Structural protein |
| A12L | 131 | 192 | Late | Core protein | Structural protein |
| A26L | 149 | 500 | Late | Gene fragment, cowpox A-type inclusion protein | Structural protein |
| A24R | 144 | 1164 | Early/late | DNA-dependent RNA polymerase subunit rpo132 | Viral regulation |
| A33R | 156 | 185 | Early/late | EEV membrane phosphoglycoprotein | Structural protein |
| A35R | 158 | 176 | Early | Unknown | Unknown |
| A44L | 170 | 346 | Early | Hydroxysteroid dehydrogenase | Viral regulation |
| A47L | 173 | 252 | Early | Unknown | Unknown |
| A52R | 178 | 190 | Late | Toll/L-1R | Virulence factor |
| B2R | 184 | 219 | Early | Unknown | Unknown |
| B10R | 192 | 166 | Unknown | Unknown | Unknown |
| B16R | 197 | 326 | Late | IL-1β inhibitor | Virulence factor |
| B19R | 200 | 351 | Early | IFN-α/β-receptor-like secreted glycoprotein | Virulence factor |
| B22R/B28R/C22L | 4/215 | 122 | Unknown | TNF-γ receptor-like | Virulence factor |
| C9L | 19 | 635 | Early | Ankyrin-like protein | Unknown |
| C6L | 22 | 151 | Early | Unknown | Unknown |
| C10L | 10/209 | 331 | Early | Unknown | Virulence factor |
| D1R | 106 | 844 | Early | Large subunit of mRNA capping enzyme | Viral regulation |
| D4R | 109 | 218 | Early | Uracil-DNA glycosylase | Viral regulation |
| D5R | 110 | 785 | Early/late | NTPase interacts with A20R | Viral regulation |
| D13L | 118 | 551 | Late | Rifampicin target | Structural protein |
| E2L | 58 | 737 | Early | Unknown | Unknown |
| E3L | 59 | 190 | Early | dsRNA-binding protein | Virulence factor |
| E6R | 62 | 567 | Late | Unknown | Unknown |
| E9L | 65 | 1006 | Early | DNA polymerase | Viral regulation |
| F1L | 40 | 226 | Early | Inhibits apoptosis | Virulence factor |
| F2L | 41 | 147 | Early | dUTPase | Viral regulation |
| F4L | 43 | 319 | Early | Ribonucleotide reductase small subunit | Viral regulation |
| F11L | 50 | 348 | Early | Unknown | Unknown |
| G9R | 87 | 340 | Late | Myristylprotein | Viral regulation |
| H4L | 102 | 795 | Late | RAP94 | Viral regulation |
| I4L | 73 | 771 | Early | Ribonucleotide reductase large subunit | Viral regulation |
| I5L | 74 | 79 | Late | IMV protein VP13 | Structural, protein |
| I6L | 75 | 382 | Late | Unknown | Unknown |
| I8R | 77 | 676 | Early | RNA-helicase, DExH-NPH-II | Viral regulation |
| J4R | 96 | 185 | Late | DNA-dependent RNA polymerase subunit rpo22 | Viral regulation |
| J6R | 98 | 1286 | Early/late | DNA-dependent RNA polymerase subunit rpo147 | Viral regulation |
| L3L | 90 | 350 | Late | Unknown | Viral regulation |
| M1L | 30 | 472 | Early | Ankyrin-like protein | Unknown |
| N2L | 29 | 175 | Early | α-amanitin target | Unknown |
| O1L | 68 | 666 | Late | Unknown | Unknown |
N.C. = no classification