Skip to main content
. Author manuscript; available in PMC: 2008 Sep 12.
Published in final edited form as: J Nat Prod. 2006 Mar;69(3):351–355. doi: 10.1021/np050327j

Figure 2.

Figure 2

Figure 2

Figure 2

Effect of purified curcuminoids on joint inflammation. Female Lewis rats were injected on day 0 with SCW (25 μg/g) or vehicle. Joint swelling was assessed by daily calculation of the arthritic index (mean ± SEM) with statistical significance was determined by Students’ T test as described in methods. (A) Purified curcuminoids (4 mg curcuminoids/kg/d) or vehicle alone ip injections were begun 4 days prior to SCW administration (n=11 animals/group) and continued on a daily basis until 10 days after SCW injection at which time treatment frequency decreased to 5 days/week. * p < 0.02. (B) Purified curcuminoids (4 mg/kg/d) or vehicle alone ip injections were begun 4 days prior to SCW administration (n=5 animals/group) and continued daily for only 5 days with last dose 6 hours prior to SCW administration. * p < 0.01. (C) Purified curcuminoids (117 mg/kg/d) or vehicle alone were administered orally 4 days prior to SCW administration (n=10–11 animals/group) and continued on a daily basis until 10 days after SCW injection at which time treatment frequency decreased to 5 days/week. * p < 0.05.