Figure 5.

rSPARC inhibits proliferation of SPARC-null cells to a greater degree than wild-type counterparts. Wild-type (black bars) and SPARC-null mesangial cells (white bars) were grown as described in Figure 4, except that 0.9 μM rSPARC was added at the time of stimulation. Equal volumes of buffer were added to control wells (see MATERIALS AND METHODS). Error bars represent the SEM.