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. Author manuscript; available in PMC: 2008 Sep 12.
Published in final edited form as: Nat Med. 2006 Oct 15;12(11):1301–1309. doi: 10.1038/nm1492

Figure 2.

Figure 2

Increased levels of virus-specific T cells after Cl 13 infection of IL-10–deficient mice. (a) Virus-specific CD4+ T cells visualized by I-Ab GP61—80 tetramer staining on day 9 after infection. Flow plots illustrate the frequency of tetramer-positive CD4+ T cells in Cl 13–infected C57BL/6 and Il10−/− mice. The bar graph illustrates the average ± 1 s.d. of tetramer-positive cells on day 9 after Arm or Cl 13 infection of C57BL/6 (black) and Cl 13 infection of IL-10–deficient (gray) mice. *P < 0.03. (b) Virus-specific CD8+ T cells visualized as in a with H-2Db GP33–41 tetramers. Flow plots illustrate tetramer-positive cells in Cl 13–infected C57BL/6 and Il10−/− mice. *P < 0.03. (c) Individual epitope-specific T-cell responses, assessed by ex vivo peptide stimulation with the indicated LCMV peptides on day 9 after Cl 13 infection of C57BL/6 or Il10−/− mice. Flow plots are gated on CD4+ or CD8+ T cells and numbers illustrate the frequency of IFN-γ+ CD4+ and CD8+ T cells. Data are representative of four mice per group and two different experiments.