Table 4.
Functional categories of genes regulated by the Zap1 transcriptional factor.
| Functional Group | Zap1 Target Genes |
| First-line defenses: Zinc homeostasis | |
| Zinc uptake | ZRT1, ZRT2, FET4, ZPS1 |
| Mobilize zinc stores | ZRT3 |
| Increase transcription response | ZAP1 |
| Zinc sparing | ZRR1 (ADH1), ZRR2 (ADH3), ADH4 |
| Zinc shock resistance | ZRC1 |
| Other zinc homeostasis genes | IZH1, IZH2 |
| Second-line defenses: Adaptive responses | |
| Secretory pathway function | ZRG17, MNT2, MCD4, YJR061W |
| Cell wall function | PST1, BAG7, HSP12, SED1, SCW4, YOL155C, YIL169C, YJL171C |
| Stress resistance | GRE2, RAD27, TSA1, CTT1, UTH1, HSP26 |
| Phospholipid metabolism | DPP1, EKI1, PIS1, YJL132W |
| Sulfur metabolism | LAP3, SAM3, YPR003C |
| Protein degradation | PRC1, PEP4, PRB1, ATG19, UBX6 |
| Carbohydrate metabolism | NRG2, TKL2, ENO1, ENO2, TDH1 |
| Purine/pyrimidine metabolism | URA10, ADE17, HNT1 |
| Mitochondrial function | FMP43, PET20, PET10 |
| Other | VEL1, MOH1, GPG1, COS6, ICY2, COS1, PHM7, PIG2, TIS11, ALD3, PUT4, COS2, ZIP1, COS4, COS8, TPO5, COS3, YNL254C, YOR387C, YLL020C, YOL131W, YBL029W, YHR214W-A, YMR181C, YLL053C , YBL048C, YMR086W, YNL234W |
Genes shown in bold are new targets in this study